论文部分内容阅读
目的探讨窒息新生儿血清胱蛋白酶抑制剂C(Cys C)水平在评价新生儿窒息后肾损害的意义。方法以68例窒息新生儿为研究对象,按Apgar评分分为轻度窒息组(47例)和重度窒息组(21例);以40例健康足月新生儿作为对照组,在入院后抽取外周静脉血3mL,检测各组血清Cys C水平,并与血清尿素氮(BUN)、肌酐(Cr)等指标进行相关性分析。采用SPSS 10.0软件进行多因素方差分析和χ2检验比较其差异。结果在对照组、轻度窒息组和重度窒息组中,血清Cys C水平分别为(0.85±0.31)mg/L,(1.77±0.37)mg/L和(2.61±0.47)mg/L,血清BUN水平分别(4.61±1.16)mmol/L、(6.58±1.33)mmol/L和(8.73±2.67)mmol/L,血清Cr水平分别为(48.51±12.89)μmol/L,(49.93±14.62)μmol/L和(71.36±13.33)μmol/L,与对照组及轻度窒息组相比,重度窒息组血清BUN、Cr和Cys C水平显著升高,差异有显著性(P<0.01)。三组之间对比Cys-C均有显著统计学意义,而BUN和Cr在对照组与轻度窒息组间差别无显著性。结论 Cys C是评价新生儿窒息后肾小球滤过功能损害的敏感指标。
Objective To investigate the significance of serum cystatin C (Cys C) levels in neonatal asphyxia after asphyxia. Methods Sixty-eight neonates with asphyxia were divided into mild asphyxia group (n = 47) and severe asphyxia group (n = 21) according to Apgar score. 40 healthy full-term newborns were used as control group, Venous blood 3mL, serum Cys C levels were measured, and serum urea nitrogen (BUN), creatinine (Cr) and other indicators were analyzed. Multivariate analysis of variance and χ2 test were used to compare the differences using SPSS 10.0 software. Results The levels of serum Cys C in the control group, mild asphyxia group and severe asphyxia group were (0.85 ± 0.31) mg / L, (1.77 ± 0.37) mg / L and (2.61 ± 0.47) mg / L, (4.61 ± 1.16) mmol / L, (6.58 ± 1.33) mmol / L and (8.73 ± 2.67) mmol / L respectively, serum Cr levels were (48.51 ± 12.89) μmol / L and (49.93 ± 14.62) μmol / L and (71.36 ± 13.33) μmol / L, respectively. Serum levels of BUN, Cr and Cys C in severe asphyxia group were significantly higher than those in control group and mild asphyxia group (P <0.01). Cys-C between the three groups was statistically significant, while BUN and Cr in the control group and mild asphyxia group no significant difference. Conclusion Cys C is a sensitive index to evaluate glomerular filtration dysfunction after neonatal asphyxia.