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目的:探讨膀胱部分切除术(PC)联合放化疗治疗肌层浸润性膀胱癌(MIBC)的效果。方法:回顾性分析我院符合纳入研究标准的112例MIBC患者的临床资料,按手术方式将患者分为根治性膀胱全切除术(RC)组(32例)和PC组(80例)。治疗结束后评价两组总体生存率、无病生存率和生存质量(EORTC-QLQ-C30评分)。结果:治疗后,PC组总体生存率、无病生存率、生存质量(EORTC-QLQ-C30评分)均高于RC组,差异均有统计学意义(均P<0.05)。结论:PC+放化疗治疗MIBC能显著提高患者的生存率与术后生活质量,延长生存时间,值得临床推广。
Objective: To investigate the effect of partial cystectomy (PC) in combination with chemoradiotherapy on muscular invasion of bladder cancer (MIBC). Methods: The clinical data of 112 MIBC patients in our hospital who met the criteria of the study were retrospectively analyzed. The patients were divided into radical cystectomy group (32 cases) and PC group (80 cases) by surgery. After treatment, the overall survival, disease-free survival and quality of life (EORTC-QLQ-C30) were evaluated. Results: After treatment, the overall survival rate, disease-free survival rate and quality of life (EORTC-QLQ-C30) in PC group were significantly higher than those in RC group (all P <0.05). Conclusion: PC + radiotherapy and chemotherapy for MIBC can significantly improve the survival rate of patients and postoperative quality of life, prolong the survival time, worthy of clinical promotion.