论文部分内容阅读
目的:观察放射性粒子植入联合支气管动脉灌注(BAI)化疗非小细胞肺癌(NSCLC)的临床疗效。方法:符合NSCLC患者88例,随机均分成观察组和对照组,观察组采用放射性粒子植入联合BAI化疗,对照组采用单一的BAI化疗;评价治疗后1月、3月及6月时的治疗效果,比较死亡率及恶心、腹泻、脱发及骨髓抑制等不良反应。结果:两组患者均完成4个周期的治疗,治疗后1、3、6个月时观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后1月和3月无死亡病例、治疗6月死亡1例,死亡例数明显低于对照组,差异有统计学意义(P<0.05);观察组患者恶心、呕吐、脱发及骨髓抑制反应的发生率低于对照组(P<0.05)。结论:放射性粒子植入联合BAI化疗对NSCLC的疗效优于单一的BAI灌注化疗。
Objective: To observe the clinical efficacy of radioactive seed implantation combined with bronchial artery infusion (BAI) chemotherapy in non-small cell lung cancer (NSCLC). Methods: A total of 88 patients with NSCLC were randomly divided into observation group and control group. The observation group received radioactive seed implantation combined with BAI chemotherapy and the control group received single BAI chemotherapy. The treatment was evaluated at January, March and June after treatment Effect, compare mortality and nausea, diarrhea, hair loss and bone marrow suppression and other adverse reactions. Results: The two groups of patients completed 4 cycles of treatment. The effective rate of the observation group was higher than that of the control group at 1, 3, and 6 months after treatment (P <0.05) There were no deaths in March and 1 death in June, the number of deaths was significantly lower than the control group (P <0.05). The incidence of nausea, vomiting, hair loss and bone marrow suppression in the observation group was lower than that in the control group Control group (P <0.05). CONCLUSION: Radioactive seed implantation combined with BAI chemotherapy is superior to single BAI chemotherapy in NSCLC.