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有机组在合成喹硫磷的过程中,发现中间体2—羟基喹恶啉有一定络合能力。文献中尚无2—羟基喹恶啉络合物研究的报导。从分子结构上看,2—羟基喹恶啉在整合时将形成四元环或畸变很大的五元环,环的张力很大,成络作用很差。但与其同分异构物5—羟基喹恶啉相比,其碱性应较强,成络作用亦应较大。5—羟基喹恶啉已被系统研究过。为探讨螯环张力与配体碱性大小对络合物稳定性影响的相对大小,对2—羟基喹恶啉的成络作用进行了初步研究。鉴于2—羟基喹恶啉及其络合物在水溶液中的溶解度较小,我们采用
Organic group in the process of the synthesis of quetiapine, found that the intermediate 2-hydroxyquinoline has some ability to complex. There are no reports of 2-hydroxyquinoxaline complexes in the literature. From the molecular structure point of view, 2-hydroxyquinoline in the integration will form a four-membered ring or distortion of a large five-membered ring, the tension of the ring, the role of poor network. However, compared with its isomer 5-hydroxyquinoline, its alkalinity should be stronger and the network effect should be larger. 5-Hydroxyquinoxaline has been systematically studied. In order to investigate the relative size of the effect of the diameter of the chelating ring and the basicity of the ligand on the stability of the complex, the formation of 2-hydroxyquinoxaline was studied. In view of 2-hydroxyquinoline and its complex solubility in aqueous solution smaller, we use