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本文研究静脉注射多巴胺对心力衰竭患者的心、肾血流动力学的影响。结果发现,19例患者中有16例心脏指数(升/分/平方米)增加26%,心率和耗氧量没有明显改变。动脉压也无改变,体循环阻力降低。原肺循环阻力正常者注射药物后无变化,而增高者则明显。20例中有12例左室最大dp/dt平均增加58%;15例肾小球滤过率增加38%;19例肾血流量增加79%;钠排泄量增加十486%。副作用有室性早搏,心悸、胸痛和上腹不适等。根据实验及有关资料的结果,作者认为,多巴胺与异丙肾上腺素在药理作用上有一定区别。二者都增加心输出量,但多巴胺是因
This article studies the effects of intravenous dopamine on cardiac and renal hemodynamics in patients with heart failure. RESULTS: Sixteen of the 19 patients had a 26% increase in heart index (L / min / m2) with no significant change in heart rate and oxygen consumption. Arterial pressure also did not change, reducing systemic resistance. The original pulmonary circulation resistance normal after no change in the injection of drugs, while those who were significantly higher. Twelve of the 20 patients had an increase in left ventricular maximum dp / dt of 58%; 15 had a glomerular filtration rate increase of 38%; 19 had a 79% increase in renal blood flow and an increase in sodium excretion by 486%. Side effects are premature ventricular contractions, heart palpitations, chest pain and abdominal discomfort. According to the results of the experiment and related information, the author believes that there is a certain difference between the pharmacological effects of dopamine and isoproterenol. Both increase cardiac output, but dopamine is due to