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目的:研究慢性非细菌性前列腺炎(chronic abacterial prostatitis,CAP)大鼠前列腺组织中神经元特异性烯醇化酶(NSE)的表达,探讨前列腺神经内分泌细胞因子对CAP的作用及其机制。方法:将40只2月龄SD大鼠随机分为正常对照组、CAP模型组,每组20只。观察大鼠前列腺病理形态学改变,用免疫组化法和ELISA法检测NSE在大鼠前列腺中的表达情况。结果:①CAP模型组的病理形态学呈明显炎症表现;②CAP模型组NSE表达强度显著高于正常对照组。结论:NSE可能参与CAP发病过程,神经内分泌细胞功能的改变可能在慢性前列腺炎发生、发展过程中起重要作用。
Objective: To investigate the expression of neuron specific enolase (NSE) in prostate tissue of chronic abacterial prostatitis (CAP) rats and to explore the effect and mechanism of prostatic neuroendocrine cytokines on CAP. Methods: Forty two-month-old SD rats were randomly divided into normal control group and CAP model group, with 20 rats in each group. The pathological changes of the prostate were observed. The expression of NSE in the prostate was detected by immunohistochemistry and ELISA. Results: ①CAP model group showed obvious inflammatory pathology; ②CAP model group NSE expression intensity was significantly higher than the normal control group. Conclusion: NSE may be involved in the pathogenesis of CAP. The changes of neuroendocrine cell function may play an important role in the occurrence and development of chronic prostatitis.