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目的探讨慢性HBV感染者病原学特点及其与肝损害、肾损害的相关性。方法根据慢性HBV感染者的病原学特点及有无肝损害情况,将282例慢性HBV感染者分为6组,观察其各项实验室指标的情况。结果双抗原阳性患者发生肝损害的例数多于单抗原阳性患者,差异有统计学意义(P<0.05);单抗原阳性而HBV-DNA阳性患者发生肝损害的例数多于单抗原阳性而HBV-DNA阴性患者,差异有统计学意义(P<0.01);单抗原阳性有合并症者发生肝损害的例数多于无合并症者,差异有统计学意义(P<0.01);≤18岁患者发生肾损害的例数多于>18岁患者,差异有统计学意义(P<0.01);有肝损害患者发生肾损害的例数明显多于无肝损害患者,差异有统计学意义(P<0.01)。结论慢性HBV感染者是否发生肝损害与病原学特点及有无合并症有相关性,是否发生肾损害与年龄因素及有无肝损害有相关性。
Objective To investigate the etiological characteristics of chronic HBV infection and its relationship with liver damage and renal damage. Methods According to the etiological characteristics of chronic HBV infected persons and the presence or absence of liver damage, 282 chronic HBV infected patients were divided into 6 groups and their laboratory indexes were observed. Results There were more cases of liver damage in double antigen positive patients than in single antigen positive patients (P <0.05). The number of cases with single antigen positive and HBV-DNA positive was more than that with single antigen HBV-DNA negative patients, the difference was statistically significant (P <0.01); single antigen positive complications were more cases of liver damage than without complications, the difference was statistically significant (P <0.01); 18 The number of cases of kidney damage in the aged patients was more than that of the patients> 18 years of age (P <0.01). The number of renal damage cases in patients with liver damage was significantly more than that in the patients without liver damage (P <0.01) P <0.01). Conclusions The occurrence of liver damage in patients with chronic HBV infection is closely related to the etiological characteristics and the presence or absence of comorbidities. Whether renal damage occurs is related to age and liver damage.