Synthesis,Crystal Structure and Biological Activity of N-(2,6-Difluorobenzoyl)-N'-[5-(4-trifluo

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The title compound N-(2,6-difluorobenzoyl)-N’-[5-(4-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]urea(C17H9F5N4O2S,Mr = 428.34) has been synthesized by the reaction of 2-amino-5-(4-trifluoromethylphenyl)-1,3,4-thiadiazole with 2,6-difluorobenzoyl isocyanate,and its crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to monoclinic,space group P21/n with a = 10.7316(13),b = 10.5617(13),c = 16.037(2) ,β = 106.408(2)°,V = 1743.6(4) 3,Z = 4,Dc = 1.632 g/cm3,μ = 0.260 mm-1,F(000) = 864,the final R = 0.0599 and wR = 0.1420 for 3467 observed reflections with I > 2σ(I).The urea group,which adopts a planar configuration mediated by the intramolecular N-H...O hydrogen bond,is nearly coplanar with the thiadiazole and 4-trifluoromethylbenzene rings.The title compound was found to exhibit good fungicidal activity against Rhizoctonia solani and Botrytis cinerea. The title compound N- (2,6-difluorobenzoyl) -N ’- [5- (4-trifluoromethylphenyl) -1,3,4- thiadiazol-2-yl] urea (C17H9F5N4O2S, Mr = 428.34) has been synthesized by the reaction of 2-amino-5- (4-trifluoromethylphenyl) -1,3,4-thiadiazole with 2,6-difluorobenzoyl isocyanate, and its crystal structure was determined by single-crystal X-ray diffraction. Space group P21 / n with a = 10.7316 (13), b = 10.5617 (13), c = 16.037 (2) β, β = 106.408 (2) °, V = 1743.6 (4) 3, Z = 4, Dc = 1.632 g / cm3, μ = 0.260 mm-1, F (000) = 864, the final R = 0.0599 and wR = 0.1420 for 3467 observed reflections with I> 2σ (I) .The urea group, which adopts a planar configuration mediated by the intramolecular NH ... O hydrogen bond, is nearly coplanar with the thiadiazole and 4-trifluoromethylbenzene rings. The title compound was found to exhibit good fungicidal activity against Rhizoctonia solani and Botrytis cinerea.
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