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RU486是由Roussel-Uclaf公司合成的甾体化合物,它含有抗孕激素和抗肾上腺皮质激素的成分。它的作用是在靶细胞上竞争性地抑制孕激素、黄体期和妊娠期的激素。它可以口服、放入阴道或者注射用药。因为它有抗孕激素的作用,所以自1982年以来,它主要作为避孕药来研究。目前,它还处于Ⅱ期临床试验阶段,部分试验是在世界卫生组织和人口委员会的指导下进行的。至今为止,有1000名妇女因各种原因而服用RU486,它作为月经周期后半期的黄体素、房事后避孕药来研究,也用于阻断妊娠,但药物的效果限制在妊娠期。附表所示:对于小于5周的妊娠,给600mg RU486不需进行外科手术就可使大约90%的人完全排出子宫内容物,终止妊娠。如果妊娠时间较长,完全排出子宫内容物的成功率就明显
RU486 is a steroid compound synthesized by Roussel-Uclaf, which contains anti-progestin and anti-adrenal cortical hormone components. Its role is to competitively inhibit progesterone, luteal phase and gestational hormones on target cells. It can be taken orally, placed in the vagina, or injected. Because of its anti-progestin effect, it has been studied primarily as a contraceptive since 1982. Currently, it is still in phase II clinical trials, some of which were conducted under the direction of the World Health Organization and the Population Commission. So far, 1,000 women have taken RU486 for a variety of reasons, studying it as progesterone in the second half of the menstrual cycle and as a post-mortem contraceptive pill, as well as in blocking pregnancy, but the drug’s effects are limited to pregnancy. Schedule: For pregnancies less than 5 weeks, administration of 600 mg of RU486 allows approximately 90% of all uterine contents to be excreted without termination of surgery and termination of pregnancy. If the pregnancy longer, the complete success rate of uterine content is obvious