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目的:检测表皮生长因子受体(epidermal growth factor receptor,EGFR)在结直肠癌组织中的表达情况,分析其表达水平与各种主要临床病理学预后因子及长期生存的关系。方法:选取解放军307医院和301医院第二附属医院64例结直肠癌患者的石腊包埋肿瘤标本,以免疫组化方法检测结直肠癌肿瘤标本中EGFR的表达。通过单因素分析和多因素分析判断EGFR表达与临床病理学指标之间的关系;通过多因素分析(COX模型)判断EGFR表达水平与患者总生存期的关系。结果:所有患者肿瘤组织EGFR的阳性表达率为69%。T3期肿瘤EGFR阳性表达明显多于T1和T2期(P<0.05),淋巴结转移阳性者EGFR阳性表达明显多于无转移者(P<0.05),有远处转移者EGFR阳性表达明显多于无远处转移者(P<0.05);EGFR表达与患者性别、年龄、肿瘤原发部位、肿瘤大小、肿瘤分化程度等均无明显相关性。EGFR表达水平与患者总生存期无明显相关。结论:结直肠癌组织EGFR的表达与肿瘤TNM分期相关,与患者总生存期无明显相关。
OBJECTIVE: To detect the expression of epidermal growth factor receptor (EGFR) in colorectal cancer and to analyze its relationship with various major clinicopathological prognostic factors and long-term survival. Methods: Paraffin-embedded tumor specimens of 64 patients with colorectal cancer from 307 Hospital of PLA and 301 Hospital of Second Affiliated Hospital were collected for immunohistochemical detection of EGFR in colorectal cancer specimens. The relationship between EGFR expression and clinicopathological parameters was evaluated by univariate analysis and multivariate analysis. The relationship between EGFR expression and overall survival was analyzed by multivariate analysis (COX model). Results: The positive rate of EGFR in all patients was 69%. The positive expression of EGFR in stage T3 tumor was significantly higher than that in T1 and T2 stage (P <0.05). The positive expression rate of EGFR in stage T3 tumor was significantly higher than that in stage T1 and T2 stage (P <0.05) Distant metastasis (P <0.05). There was no significant correlation between EGFR expression and patient’s gender, age, primary tumor site, tumor size and tumor differentiation. There was no significant correlation between the expression of EGFR and the overall survival of patients. Conclusion: The expression of EGFR in colorectal cancer is correlated with the TNM stage of the tumor, but not with the overall survival of the patients.