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哺乳动物胚胎植入前的发育中致密化和囊胚形成分别标志着第一次、第二次细胞分化(即细胞命运决定)的起始,是胚胎正常发育的必要条件。因此对影响致密化和囊胚形成的蛋白及调节因子的研究尤为重要。本文探讨了与致密化相关的细胞黏附蛋白、连接蛋白、细胞骨架等分子和囊胚形成相关的紧密连接蛋白、钠钾三磷酸腺苷激酶等分子的一系列调控,以及致密化和囊胚形成在细胞命运决定中的重要作用。
The developmental densification and blastocyst formation before mammalian embryo implantation mark the beginning of the first and second cell differentiation (ie, the decision of cell fate), respectively, and are necessary for normal embryo development. Therefore, the study on densification and blastocyst formation of proteins and regulatory factors is particularly important. In this paper, a series of regulation of tight junction-related proteins such as cell adhesion protein, connexin, cytoskeleton and tight junction proteins related to blastocyst formation and adenosine triphosphate kinase, as well as densification and blastocyst formation in cell fate The important role of the decision.