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类固醇激素诱发的高血压是糖皮质激素治疗的严重并发症之一,尤以肾损害时更为多见。目前对其发生的机理尚有争议。本研究旨在探讨钠潴留、血容量(BV)、肾素血管紧张素系统在激素诱发产生的高血压中的作用,并筛选出有该并发症发生倾向的肾脏病患者。研究包括最初血压正常的患者共35例(女18例、男17例),年龄14～48岁,其中慢性肾炎29例、狼疮性肾炎6例。27例表现为肾病综合征(NS)。全部病例均做了肾穿刺活检。使用强的松0.7～0.8mg/kg/日,摄入钠100～200mmol/日。
Steroid-induced hypertension is one of the serious complications of glucocorticoid therapy, especially when kidney damage is more common. The current mechanism of its occurrence is still controversial. This study aimed to investigate the role of sodium retention, blood volume (BV), and renin-angiotensin system in hormone-induced hypertension and to screen for patients with kidney disease that is predisposed to this complication. The study included 35 patients (18 males and 17 females) with initial normotensive patients aged 14 to 48 years, of whom 29 had chronic nephritis and 6 had lupus nephritis. 27 cases showed nephrotic syndrome (NS). All cases were done renal biopsy. Prednisone 0.7 ~ 0.8mg / kg / day, intake of sodium 100 ~ 200mmol / day.