Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Del

• 作 者: Xiang-ru Feng 丁建勋 Ruxandra Gref Xue-si Chen
• 机 构: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of
• 出 处: Chinese Journal of Polymer Science
• 发表日期: 2017年06期
• 关键词: cholesterol lactide armed Poly micelle sustained diameters PLLA guest Controlled

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol(4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin)(PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly (ethylene glycol) -block-poly (L-lactide / D-lactide) -PLLA / PDLA-CHOL) and poly (β-cyclodextrin) (PCD) with the molar ratios of CHOL / β-CD at 1: 0.5, 1: 1, and 1: 2 in an aqueous environment. micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL / β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibits great potential in sustained drug delivery.