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目的:探讨女性原发不孕患者行短时受精和half-ICSI 2种受精方式对受精率和胚胎发育潜能的影响。方法:回顾性分析175个周期女性原发不孕患者体外助孕资料,分为短时受精和/或联合早期补救ICSI周期组(A组,114个周期,其中A1组103个短时IVF受精周期,A2组11个早期补救ICSI周期)及half-ICSI周期组(B组,61个周期),分析比较各组IVF/ICSI-ET结局。结果:B组较A组不孕年限长,获卵数多,正常受精率低,差异有统计学意义(P<0.05)。但异常受精率、优质胚胎率和临床妊娠率差异无统计学意义(P>0.05)。A1组正常受精率明显低于A2组(P<0.05),异常受精率、优质胚胎率和临床妊娠率组间差异无统计学意义(P>0.05)。不同病因对A、B组患者的妊娠结局无显著影响。结论:短时受精和/或联合早期补救ICSI对原发不孕患者是一种较为合理而安全的受精方式。
Objective: To investigate the effect of short-fertilization and half-ICSI fertilization on fertilization rate and embryonic developmental potential in female infertility patients. Methods: A retrospective analysis of 175 cycles of in vitro fertilization in female infertility patients was divided into short-term fertilization and / or combined with early recovery ICSI cycle group (A group, 114 cycles, of which A1 group of 103 short-term IVF fertilization Cycle, 11 early recovery ICSI cycles in group A2) and half-ICSI cycle group (group B, 61 cycles). The outcomes of IVF / ICSI-ET in each group were analyzed and compared. Results: Compared with group A, group B had longer duration of infertility, more oocytes and lower rate of normal fertilization, the difference was statistically significant (P <0.05). However, there was no significant difference in abnormal fertilization rate, good embryo rate and clinical pregnancy rate (P> 0.05). The normal fertilization rate in A1 group was significantly lower than that in A2 group (P <0.05). There was no significant difference between abnormal fertilization rate, high quality embryo rate and clinical pregnancy rate (P> 0.05). Different causes of pregnancy in patients with A, B group had no significant effect on pregnancy outcomes. CONCLUSIONS: Short-term fertilization and / or combined early rescue ICSI is a more rational and safe method of fertilization in patients with primary infertility.