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目的了解入伍新兵人群中C群流行性脑脊髓膜炎(简称流脑)IgG抗体的流行分布情况,为今后预防提供科学依据。方法采用血清流行病学调查方法,利用酶联免疫吸附试验(ELISA)技术,对北京军区近4年来自7个省市的360名入伍新兵血清进行了C群流脑IgG抗体检测,统计分析其阳性率。结果发现各年间入伍新兵血清中C群流脑IgG抗体历年间呈显著增高变化,为41.33%-74.07%,平均55.56%;抗体含量为0.173-77.655μg/m l,平均(4.766±8.396)μg/m l;地区间差别显著,河南省(74.07%)、湖北省(65.00%)和山东省(60.00%)较高,北京市(41.33%)和浙江省(42.22%)较低;入伍前工作与否,抗体阳性检出率无显著性差别;其差别的主要原因可能与各地区疫苗接种率、隐性感染和接种时间长短有关。结论入伍新兵人群中C群流脑IgG抗体阳性率为41.33%-74.07%,并有显著性地区差异,阳性率明显低于75%警戒线,应引起高度重视,防止C群流脑在部队人群中暴发流行;抗体平均含量为(4.766±8.396)μg/m l,所以,应在新兵入伍期间,采取预防接种、健康教育等有效预防措施。
Objective To understand the epidemiological distribution of IgG antibody in group C meningitis (Group C) meningitis in newly enrolled recruits and provide a scientific basis for future prevention. Methods Serum epidemiological investigation method was used to detect IgG antibodies against Group C meningococcal serogroup C in 360 recruits from 7 provinces and cities in the Beijing Military Region in the past 4 years by enzyme-linked immunosorbent assay (ELISA) Positive rate. The results showed that the serogroup C antibody of serogroup C was significantly increased over the years (41.33% -74.07%, average 55.56%); the antibody content was 0.173-77.655μg / ml, with an average of (4.766 ± 8.396) μg / ml. There were significant differences among regions. Henan Province (74.07%), Hubei Province (65.00%) and Shandong Province (60.00%) were higher than those in Beijing (41.33%) and Zhejiang Province (42.22% No, there is no significant difference in the positive rate of antibody; the main reason of the difference may be related to the vaccination rate, latent infection and vaccination duration in all regions. Conclusions The positive rate of serogroup C IgG in serogroup C is 41.33% -74.07%, and there are significant regional differences, the positive rate is significantly lower than the 75% alert line, which should be given high priority to prevent C group M (4.766 ± 8.396) μg / ml. Therefore, effective preventive measures such as vaccination and health education should be taken during recruits.