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观察尿激酶(UK)溶栓治疗超早期脑梗塞的疗效、安全性,探讨其用药剂量、方法、适应症;及溶栓前后血浆D-二聚体的变化。方法:对起病<6小时,或起病超过6小时,小于12小时,CT阴性的20例脑梗塞患者,采用静脉快速滴注UK30万单位,视临床症状的演变,可追加UK剂量,总剂量不超过200万单位;并对治疗前后患者的神经功能缺损进行评定,检测治疗前后血浆D-二聚体的水平。结果:UK应用后患者的临床症状明显改善,患者的平均住院日下降,血浆D-二聚体明显升高(P<0.01)。结论:UK溶栓治疗超早期脑梗塞具有疗效高、安全的特点。
To observe the curative effect and safety of urokinase (UK) thrombolysis in the treatment of ultra-early cerebral infarction, and to explore the dosage, method and indication of the therapy; and the changes of plasma D-dimer before and after thrombolysis. Methods: 20 cases of cerebral infarction with onset of less than 6 hours, or more than 6 hours, less than 12 hours and CT negative were treated with rapid intravenous infusion of 300,000 units of UK. Depending on the clinical symptoms, additional doses of UK, Dose does not exceed 2 million units; and before and after treatment in patients with neurological deficits were assessed to detect plasma D-dimer levels before and after treatment. Results: The clinical symptoms of patients with UK were significantly improved, the average length of stay in patients decreased, and the plasma D-dimer was significantly increased (P <0.01). Conclusion: UK thrombolytic therapy of ultra-early cerebral infarction with high efficacy, safety features.