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目的观察在急性冠脉综合征(acutecoronarysyndrome,ACS)患者早期使用脂质载体前列腺素E1(liposomalprostaglandinE1,Lipo PGE-1)对血浆C反应蛋白(C- reactiveprotein,CRP)、白介素6(interleukin6,IL-6)、肿瘤坏死因子(tumournecrosisfactorα,TNF-α)等炎症因子的影响。方法71例确诊ACS患者随机分成观察组(37例)和对照组(34)。前者入选后给予PGE120μg+生理盐水40ml静脉注射(<30min),2次d×3d,对照组患者则不给。其余基础治疗措施相同。入选当天及3d后抽血查CRP、IL-6、TNF-α,所得结果进行t检验。结果两组CRP、TNF-α均有明显升高[观察组(22.32±17.15)mg·L-1、(169.33±32.74)pg·ml-1,对照组(21.67±18.23)mg·L-1(157.95±33.42)pg·ml-1],IL6升高不明显[观察组(1.18±0.27)pg·ml-1,对照组(1.21±0.36)pg·ml-1]。3d后观察组CRP、TNFα明显下降[(10.87±7.54)mg·L-1(76.58±22.51)pg·ml-1],IL-6无明显变化[(1.29±0.43)pg·ml-1];而对照组CRP、IL-6、TNF-α均无明显变化[(18.42±11.26)mg·L-1、(1.13±0.12)pg·ml-1、(143.67±36.21)pg·ml-1]。结论在ACS早期CRP、TNF-α等均有不同程度升高,说明ACS早期炎症反应明显;Lipo PGE1在ACS患者早期使用可抑制CRP、TNF-α等炎症因子水平。
Objective To observe the effect of liposomal prostaglandin E1 (Lipo PGE-1) on the expression of C-reactive protein (CRP), interleukin 6 (IL- 6), tumor necrosis factor (TNF-α) and other inflammatory factors. Methods Seventy-one patients diagnosed with ACS were randomly divided into observation group (37 cases) and control group (34). The former was given after PGE120μg + saline 40ml intravenously (<30min), 2 times d × 3d, the control group patients do not give. The rest of the basic treatment of the same. Blood samples were taken for examination of CRP, IL-6 and TNF-α on the day and after 3 days. The results were analyzed by t-test. Results The levels of CRP and TNF-α were significantly increased in both groups (22.32 ± 17.15 mg · L-1, 169.33 ± 32.74 pg · ml-1 in the observation group and 21.67 ± 18.23 mg · L-1 in the control group (157.95 ± 33.42) pg · ml-1]. The level of IL6 was not significantly increased (1.18 ± 0.27 pg · ml-1 in the observation group and 1.21 ± 0.36 pg · ml-1 in the control group). The levels of CRP and TNFα in the observation group decreased significantly after 3 days [(10.87 ± 7.54) mg · L-1 (76.58 ± 22.51) pg · ml-1] and there was no significant change in IL-6 [(1.29 ± 0.43) pg · ml- ; While there were no significant changes in CRP, IL-6 and TNF-α in the control group [(18.42 ± 11.26) mg · L -1, (1.13 ± 0.12) pg · ml -1, (143.67 ± 36.21) pg · ml -1 ]. Conclusions The levels of CRP and TNF-α were all increased to some extent in the early stage of ACS, which indicated that inflammatory reaction of ACS was obvious in early stage of ACS. Lipo PGE1 could inhibit the levels of CRP and TNF-α in early stage of ACS.