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目的 :为了观察米索前列醇 (Misoprostol,米索 )用于足月妊娠引产不同给药途径 (舌下含服及阴道后穹窿给药 )的临床效果。方法 :选择有引产指征 ,无引产及米索使用禁忌症的单胎、头位的足月妊娠妇女 72例 ,随机分为 A组(舌下含服组 )、B组 (阴道后穹窿组 ) ,分别用米索 5 0 μg舌下含服及阴道后穹窿给药 ,间隔 4～ 6 h重复给药 ,2 4h内最大剂量为 2 0 0μg。结果 :两组的引产成功率分别为 95 %和 93.7%。首次用药至规律宫缩开始时间分别为 3.82± 1.2 1h和3.45± 1.42 h,首次用药至胎儿娩出时间分别为 8.6 0± 4.42和 8.82± 4.87h。两组比较 ,差异无显著性 (P>0 .0 5 )。但产后白细胞总数升高 B组明显高于 A组 (P<0 .0 5 )。结论 :采用米索前列醇 5 0 μg含服给药法引产 ,方法更为简便、易行 ,更为安全有效
OBJECTIVE: To investigate the clinical effects of misoprostol (Misoprostol) for different administrations of subacute labor (sublingual administration and vaginal fornix administration) during term pregnancy. Methods: Seventy-two full-term pregnant women with single fetus and head position with no induced labor and misoprostol use were randomly divided into group A (sublingual group), group B (vaginal fornix group ) Were administered sublingual submucosa with 50 μg of misoprostol and vaginal fornix, respectively, with repeated doses of 4 ~ 6 h. The maximum dose within 200 h was 200 μg. Results: The successful rates of induction of labor in both groups were 95% and 93.7% respectively. The initial time from first medication to regular contractions were 3.82 ± 1.2 1h and 3.45 ± 1.42 h respectively, and the first delivery to fetus was 8.6 ± 4.42 and 8.82 ± 4.87 h respectively. There was no significant difference between the two groups (P> 0.05). However, the total number of postpartum leukocytes increased significantly in group B than in group A (P <0.05). Conclusion: Misoprostol 50 μg buccal delivery method, the method is more simple, easy, more safe and effective