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目的:探讨血浆N末端脑钠肽原(NT-pro BNP)在老年脑梗死患者治疗效果及病灶面积评估中的价值。方法:85例老年脑梗死患者根据治疗效果分为好转组(15例)和恶化组(70例),根据颅脑CT或颅脑MRI结果、Pullicino公式分为大面积脑梗死(34例)、中度脑梗死(27例)、小面积脑梗死(24例),检测和比较各组血浆NT-pro BNP表达水平,同时选择30例门诊体检者作为正常对照组。结果:不同面积脑梗死患者血浆NT-pro BNP表达水平均明显高于正常对照组(P<0.05),且随着脑梗死病灶体积增大,血浆NT-pro BNP表达水平也显著性升高(P<0.05);随治疗时间逐渐延长,好转组患者血浆NT-pro BNP表达水平明显下降(P<0.05),而恶化组患者血浆NT-pro BNP表达水平明显升高(P<0.05)。结论:血浆NT-pro BNP表达水平不但可预测脑梗死病变程度,还可评估治疗效果和预后情况,是一种敏感的实验室指标。
Objective: To investigate the value of plasma N-terminal pro-brain natriuretic peptide (NT-pro BNP) in the evaluation of therapeutic effect and lesion area in elderly patients with cerebral infarction. Methods: A total of 85 elderly patients with cerebral infarction were divided into improved group (n = 15) and worsening group (n = 70) according to the therapeutic effect. According to the results of brain CT or brain MRI, Pullicino formula was divided into large area cerebral infarction Moderate cerebral infarction (n = 27) and small area cerebral infarction (n = 24). The plasma levels of NT-pro BNP in each group were detected and compared. 30 outpatients were selected as the normal control group. Results: The plasma levels of NT-pro BNP in patients with different infarct volumes were significantly higher than those in the normal control group (P <0.05), and the expression of plasma NT-pro BNP was also significantly increased with the increase of infarct volume (P <0.05). With the prolongation of treatment time, the expression of plasma NT-pro BNP in patients with remission was significantly decreased (P <0.05), while that of patients with worsening was significantly increased (P <0.05). Conclusion: The expression level of plasma NT-pro BNP not only can predict the degree of cerebral infarction, but also evaluate the therapeutic effect and prognosis. It is a sensitive laboratory index.