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促血管生成素(Ang)是新近发现的一种重要的血管生成调节因子,调节血管静息状态、退化与新生之间的精细平衡,参与生理性和病理性血管生成,并与血管内皮生长因子(VEGF)等其他促血管生成因子相互作用,共同促进肿瘤性血管的生成。已有研究证实其与多种良恶性肿瘤,包括妇科肿瘤的发生发展有密切关系,随着其相关研究的进展,Ang将成为肿瘤靶向治疗的热点。
Angiogenin (Ang) is a recently discovered important regulator of angiogenesis, regulating the resting state of blood vessels, the fine balance between degeneration and neogenesis, participating in physiological and pathological angiogenesis, and is associated with vascular endothelial growth factor (VEGF) and other angiogenic factors interact to jointly promote tumor angiogenesis. Studies have confirmed that it is closely related to the occurrence and development of various benign and malignant tumors, including gynecologic tumors. With the progress of related research, Ang will become a hot spot in tumor targeted therapy.