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大量研究表明,通过测定血清、卵泡液或动物胚胎上的细胞因子,发现这些细胞因子对体外受精-胚胎移植的受精率、优质胚胎形成率、妊娠结局有着紧密联系,细胞因子在体外受精-胚胎移植妇女卵泡液中、血清中水平的增加;通过受体介导,以自身分泌、旁分泌及远距离作用形式对下丘脑垂体卵巢进行调控,并参与人体胚胎植入,妊娠维持及胎盘激素合成分泌过程的调节。随着体外受精胚胎移植技术的日新月异,卵巢内微循环调节卵泡发育的细胞因子的作用日益受到重视。
Numerous studies have shown that these cytokines are closely linked to fertilization rate, high quality embryogenesis rate and pregnancy outcome by measuring cytokines in serum, follicular fluid or animal embryo. In vitro fertilization-embryos Transplantation of follicular fluid in women, increased serum levels; by receptor-mediated, with its own secretory, paracrine and long-term role in the regulation of hypothalamus pituitary ovarian and involved in human embryo implantation, pregnancy maintenance and placental hormone synthesis Regulation of the secretion process. With the ever-changing technology of in vitro fertilization embryo transfer, the role of ovarian microcirculation in regulating the development of follicular cytokines is gaining more and more attention.