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Cohen等发现,洛杉矶大气CO污染与急性心肌梗塞病人死亡率之间有密切关系。De-Bias等证实,吸入100 ppmCO 6小时是患急性心肌梗塞猴和正常猴心室纤颤发生率增加的重要因素。作者曾观察到,21只患急性心肌梗塞的狗吸入100 ppmCO2小时,动脉血HbCO平均值升高为6.34±0.53%,心室纤颤阈(VFT)显著下降(P<0.001)。在本文中,作者研究了吸入100 ppmCO或吸入纯压缩空气2小时对20只麻醉开胸的正常狗VFT的影响。
Cohen et al. Found that there is a close relationship between atmospheric CO pollution in Los Angeles and mortality in patients with acute myocardial infarction. De-Bias and other confirmed that inhalation of 100 ppmCO 6 hours is suffering from acute myocardial infarction monkeys and normal monkeys increased the incidence of ventricular fibrillation an important factor. The authors observed that inhalation of 100 ppm CO2 for 21 acute myocardial infarction dogs resulted in an increase of 6.34 ± 0.53% in arterial blood HbCO and a significant decrease in ventricular fibrillation threshold (VFT) (P <0.001). In this article, we investigated the effect of inhaling 100 ppmCO or inhaling pure compressed air for 2 hours on the normal anesthesia in 20 open-chest VFTs.