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一、白血病的病因调查(一)化学药品与白血病1.河南白血病协作组分析白血病556例,发病前有药物接触史者406例(73.02%):农药(主要为有机磷DDT等)173例(31.4%);氯或合霉素103例(18.52%);解热止痛剂29例(7.14%);苯类27例(6.65%);抗疟药25例(6.16%);抗菌素24例(5.91%);保泰松19例(4.68%);其他5例(1.3%)。广西省荔浦县人民医院报导1例于120个月内不规则服用氯霉素后发生急性单核白血病。武汉市第八人民医院报导1例因肺炎应用氯霉素后半个月发生再障,最后转变为急性粒细胞型白血病。2.湖北省襄阳地区人民医院及武汉医学院一院对密切长期接触苯、甲苯、三甲苯的439名工人进行了健康及血液学方面的检查,发现192名(43.7%)有神经衰弱的症状。白细胞数低于5,000者67例(15.3%),
First, the etiology of leukemia (a) of chemicals and leukemia 1. Henan leukemia group analysis of leukemia in 556 cases, before the onset of drug exposure history of 406 cases (73.02%): pesticides (mainly organic phosphorus DDT, etc.) 173 cases 31.4%); 103 cases (18.52%) of chloramphenicol; 29 cases of antipyretic analgesics (7.14%); 27 cases of benzene (6.65%); 25 cases of antimalarial drugs 5.91%), phenylbutazone in 19 cases (4.68%) and the other 5 cases (1.3%). A case of acute monocytic leukemia was reported in one case of Lipu County People’s Hospital of Guangxi Province after an irregular dose of chloramphenicol within 120 months. Wuhan Eighth People’s Hospital reported a case of pneumonia caused by chloramphenicol half a month after the occurrence of aplastic anemia, and finally transformed into acute myeloid leukemia. 2. The People’s Hospital of Xiangyang in Hubei Province and the First Hospital of Wuhan Medical College conducted a survey on health and hematology of 439 workers who were in close contact with benzene, toluene and trimethylbenzene. It was found that 192 (43.7%) patients had neurasthenic symptoms . Sixty-seven cases (15.3%) had leukocytes less than 5,000,