论文部分内容阅读
PURPOSE: We report a case of autoimmune lymphoproliferative syndrome (ALPS) pr esenting with bilateral uveitis. DESIGN: Observational case report. METHODS: Rev iew of case record, serum and aqueous IL-10 and IL-6 cytokine results, and imm unosuppressive treatment of a patient with a mutation in the gene encoding Fas. RESULTS: Control of the intermediate uveitis required sustained doses of topical and periocular corticosteroids as well as systemic cyclosporine. The serum IL- 10 level was elevated, as commonly seen in ALPS, but the aqueous IL-10 was not. CONCLUSIONS: Despite a Th2 immune predominance in ALPS, uveitis, a Th1-mediate d disease, may still manifest in these patients. The pathogenesis of uveitis in ALPS may differ from that of the systemic disease overall. Long-term follow-up is required for patients with uveitis associated with ALPS.
METHODS: Rev iew of case record, serum and aqueous IL-10 and IL-6 cytokine results, and imm unosuppressive treatment. PURPOSE: We report a case of autoimmune lymphoproliferative syndrome (ALPS) pr esenting with bilateral uveitis. of a patient with a mutation in the gene encoding Fas. RESULTS: Control of the intermediate uveitis required sustained doses of topical and periocular corticosteroids as well as systemic cyclosporine. The serum IL- 10 level was elevated, as commonly seen in ALPS, but the CONCLUSIONS: Despite a Th2 immune predominance in ALPS, uveitis, a Th1-mediate d disease, may still manifest in these patients. The pathogenesis of uveitis in ALPS may differ from that of the systemic disease overall. Long -term follow-up is required for patients with uveitis associated with ALPS.