论文部分内容阅读
取代苯胺与N,N’-双(2-氯乙基)胺盐酸盐在二乙二醇单甲醚溶剂中,微波辐射下一步合成了10种N-芳基取代哌嗪盐酸盐,反应在3～4 min内完成,产率36.9%～75.4%。结果表明,苯胺芳环上的取代基对N-芳基哌嗪化反应有着可合理预测的电子效应及位阻效应。与常规加热法相比,微波辐射法具有反应时间短、产率高、操作简便和环境友好等特点。所有产物的分子结构用IR、1HNMR和MS进行了表征。
Substituted aniline and N, N’-bis (2-chloroethyl) amine hydrochloride in diethylene glycol monomethyl ether solvent under microwave irradiation synthesized 10 N-aryl substituted piperazine hydrochloride, The reaction was completed in 3 ~ 4 min, yield 36.9% ~ 75.4%. The results show that the substituents on the anilino aromatic ring have a reasonably predictable electronic effect and steric hindrance on the N-aryl piperazidation reaction. Compared with the conventional heating method, the microwave irradiation method has the advantages of short reaction time, high yield, easy operation and environment friendliness. The molecular structures of all the products were characterized by IR, 1HNMR and MS.