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目的 :探讨胃舒胶囊治疗慢性萎缩性胃炎 (CAG)癌前病变的机制。方法 :采用甲硝基亚硝基胍(MNNG)、雷尼替丁及饥饱失常的综合方法 ,造成大鼠 CAG癌前病变气虚血瘀病证结合的动物模型。 12 5只大鼠随机分为 8组 :正常对照预防与治疗组、模型组、自然恢复组、维甲酸预防与治疗组、胃舒胶囊预防与治疗组 ,观察各组大鼠血液红细胞 (RBC)免疫功能的变化。结果 :模型组及自然恢复组大鼠 RBC- C3b受体花环率降低 ,RBC免疫复合物 (BRC- IC)花环率增高 ,胃舒胶囊预防与治疗组、维甲酸预防与治疗组以上指标均有改善 ,但胃舒胶囊对RBC- IC花环率的降低作用好于维甲酸 (P <0 .0 5 )。结论 :胃舒胶囊能显著改善和调节 RBC免疫功能 ,清除体内免疫复合物 ,这可能是胃舒胶囊防治大鼠 CAG癌前病变的机制之一
Objective: To investigate the mechanism of Weishu capsule in the treatment of precancerous lesions of chronic atrophic gastritis (CAG). Methods: An animal model of combination of nitroguanidine (MNNG), ranitidine and impatient hunger syndrome was used to induce the combination of Qi-deficiency and blood-stasis syndrome in rats with precancerous lesions of CAG. One hundred and twenty five rats were randomly divided into 8 groups: normal control group, model group, natural recovery group, retinoic acid prevention and treatment group, Weishu capsule prevention and treatment group, blood red blood cell (RBC) Changes in immune function. Results: The rosette rate of RBC-C3b receptor decreased and the rate of rosette of RBC immune complex (BRC-IC) increased in model group and spontaneous recovery group. The indexes of Weishu capsule prevention and treatment group and retinoic acid prevention and treatment group all had However, Wei Shu capsule decreased RBC-IC rosette rate better than retinoic acid (P <0.05). Conclusion: Weishu capsule can significantly improve and regulate immune function of RBC and eliminate immune complexes in vivo, which may be one of the mechanisms of Weishu capsule in preventing precancerous lesions of CAG in rats