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三体11是血液疾病中继三体8、三体12和三体21之后第4个最常见的常染色体三体,约见于～1％的急性髓性白血病(AML)和骨髓增生异常综合征(MDS)。为探讨其临床病理学特征和预后意义,作者对1989至1993年间发现的15例伴有三体11的AML/MDS作了回顾性分析。 15例患者中,男12例,女3例,年龄34～79岁,中数55岁。其白血病类型计有M_27例,M_15例,M_3、M_4和M_5各1例。涉及三系的病态造血改变(MDS)见于5例初诊时和1例复发时。除1例未检外,其余14例的
Trisomy 11 is the fourth most common autosomal trisomy following hematological disease relapsing trisomy 8, trisomy 12 and trisomy 21. About ~ 1% of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). To explore its clinicopathological features and prognostic implications, the authors retrospectively reviewed 15 AML / MDS cases with trisomy 11 that were found between 1989 and 1993. Among the 15 patients, there were 12 males and 3 females, aged 34-79 years and 55 years old. The type of leukemia there M_27 cases, M_15 cases, M_3, M_4 and M_5 in 1 case. The morbid hematopoietic changes (MDS) involving three lines were found in 5 cases at first visit and one at recurrence. In addition to 1 case not seized, the remaining 14 cases