论文部分内容阅读
50%甘油溶液有多种临床用途,眼科常用于急性青光眼。现将其在眼科的临床应用、药理作用、不良反应及处方改进介绍如下:甘油是一种丙三醇,为无色油状液体、味甜,可溶于水及酒精中,几乎不溶于乙醚。它存在于正常的机体中,口服后大部分在肝脏中转化为葡萄糖、糖原及其它碳水化合物,其小部分构成其它脂肪类。甘油可氧化成二氧化碳和水,且产生4.32千卡/克热量,较葡萄糖的产热量略高。在眼科中常利用其脱水作用,如角膜水肿可滴甘油使角膜暂时变为清亮。口服甘油后经消化道迅速吸收,30分钟后眼压开始下降,11/2～2小时降压最显著,可维持4～6小时,一般8小时可恢复原来水平。适用于各种类型的青光眼(包括急性闭角型青光眼、慢性闭角型青光
50% glycerol solution has a variety of clinical uses, ophthalmology commonly used in acute glaucoma. Now its clinical application in ophthalmology, pharmacological effects, adverse reactions and prescription improvements are as follows: Glycerol is a glycerol, a colorless oily liquid, sweet, soluble in water and alcohol, almost insoluble in ether. It is found in the normal body, and most of it is converted to glucose, glycogen and other carbohydrates in the liver after oral administration, and a small portion of it forms other fats. Glycerol can be oxidized to carbon dioxide and water, and produces 4.32 kcal / g calories, slightly more heat than glucose. Often used in ophthalmology, dehydration, such as corneal edema can make glycerol to make the cornea temporarily become clear. After oral administration of glycerol rapidly absorbed through the digestive tract, intraocular pressure began to decline after 30 minutes, 11/2 ~ 2 hours the most significant step-down, can be maintained for 4 to 6 hours, usually 8 hours to restore the original level. Suitable for all types of glaucoma (including acute angle-closure glaucoma, chronic angle-closure glaucoma