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目的探讨Castleman病的临床病理特点。方法通过常规组织病理和免疫组织化学等方法观察8例Castleman病并结合相关文献进行分析。结果 8例Castleman病中男3例,女5例,其中局限型6例,均为玻璃样血管型,多中心型2例,玻璃样血管型及浆细胞型各1例。结论 Castleman病是一种特殊类型的淋巴组织增生性疾病,可发生于任何年龄,该病的诊断和分型主要依靠组织病理学;手术治疗是首选,化疗、放疗及生物治疗等多种方法联合应用,有助于控制本病发展。
Objective To investigate the clinicopathological features of Castleman’s disease. Methods Eight cases of Castleman’s disease were observed by routine histopathological and immunohistochemical methods and analyzed with related literatures. Results There were 3 males and 5 females in 8 cases of Castleman’s disease, of which 6 were localized type, all of which were of vitreous vascular type, 2 of multicentric type and 1 of vitreous vascular type and plasma cell type. Conclusions Castleman’s disease is a special type of lymphoproliferative disease that can occur at any age. The diagnosis and classification of this disease depends mainly on histopathology. Surgical treatment is the first choice, and chemotherapy, radiotherapy and biological therapy are combined Application, help to control the development of this disease.