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1983年W illiam W addell最先报道非甾体类抗炎药(nonsteroidal anti-inflamm atory drugs,NSAID s)可减少家族性腺瘤性息肉病(FAP)患者的结直肠腺瘤。其后在动物及人体的研究中也证明有规律地服用NSAID s可减少发生结肠癌、直肠癌的危险。许多良性癌前病变和恶性肿瘤如结直肠
In 1983, W illiam W addell first reported that nonsteroidal anti-inflammtory drugs (NSAIDs) can reduce colorectal adenoma in patients with familial adenomatous polyposis (FAP). Subsequent studies in animals and humans have also demonstrated that regular administration of NSAIDs reduces the risk of developing colon and rectal cancers. Many benign precancerous lesions and malignancies such as colorectal