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目的探讨阿托伐他汀钙对缺血性脑卒中再发的预防作用。方法将100例首次患缺血性脑卒中的患者经积极治疗病情平稳后,随机分为对照组50例,治疗组50例。对照组常规予以阿司匹林肠溶片100mg/日。治疗组在对照组治疗的基础上予以阿托伐他汀钙20mg/日,共服用1年,分析两组血脂变化、颈动脉斑块积分的变化及缺血性脑卒中再发的比率。结果治疗组低密度脂蛋白胆固醇(2.63±1.25)mmol/L,对照组(4.38±1.85)mmol/L,两组比较差异有统计学意义(t=2.426,P﹤0.05)。治疗组颈动脉斑块积分(4.05±2.16),对照组颈动脉斑块积分(6.51±2.23),两组比较差异有统计学意义(t=2.851,P﹤0.05)。缺血性脑卒中再发的比率治疗组和对照组分别为(5%)和(16%),两组比较差异有统计学意义(χ2=4.80,P﹤0.05)。结论阿托伐他汀钙能有效预防缺血性脑卒中的再发。
Objective To investigate the preventive effect of atorvastatin calcium on recurrent ischemic stroke. Methods 100 cases of first ischemic stroke patients after active treatment of stable disease were randomly divided into control group of 50 patients, the treatment group of 50 patients. Control group routinely given aspirin enteric-coated tablets 100mg / day. The treatment group received atorvastatin calcium 20 mg / day on the basis of the treatment of the control group for a total of 1 year. The changes of the blood lipid, carotid plaque score and rate of recurrent ischemic stroke were analyzed. Results The LDL cholesterol (2.63 ± 1.25) mmol / L in the treatment group and 4.38 ± 1.85 mmol / L in the control group were significantly different (t = 2.426, P <0.05). The carotid plaque score (4.05 ± 2.16) and carotid artery plaque score (6.51 ± 2.23) in the treatment group were significantly different between the two groups (t = 2.851, P <0.05). The rate of recurrent ischemic stroke was (5%) and (16%) in the treatment group and the control group, respectively, with significant difference between the two groups (χ2 = 4.80, P <0.05). Conclusion Atorvastatin calcium can effectively prevent ischemic stroke recurrence.