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目的分析探讨硫唑嘌呤治疗顽固性溃疡性结肠炎的临床效果。方法选取贵州省清镇市第一人民医院2011年5月～2012年5月收治的顽固性溃疡性结肠炎患者60例作为研究对象,将其分为对照组和试验组,每组30例。试验组采用硫唑嘌呤进行治疗,对照组患者给予常规药物治疗,观察分析两组患者临床疗效,计量资料采用t检验,计数的资料采用χ2检验,P<0.05为差异有统计学意义。结果试验组临床总有效率为83.33%,对照组总有效率为60.00%,两组相比差异有统计学意义(P<0.05)。1年后随访中,试验组复发率为40.00%,对照组复发率为100.00%,两组相比差异有统计学意义(P<0.05)。结论采用硫唑嘌呤治疗顽固性溃疡性结肠炎患者,可以提高疾病治疗效果,值得在实际中推广。
Objective To investigate the clinical effect of azathioprine on refractory ulcerative colitis. Methods Sixty patients with refractory ulcerative colitis admitted to the First People’s Hospital of Qingzhen City, Guizhou Province from May 2011 to May 2012 were selected as study subjects, which were divided into control group and experimental group with 30 cases in each group. The experimental group was treated with azathioprine. The patients in the control group were given conventional drug therapy. The clinical efficacy was observed and analyzed in both groups. The t test was used to measure the data and the χ2 test was used to count the data. The difference was statistically significant at P <0.05. Results The total clinical effective rate was 83.33% in the experimental group and 60.00% in the control group. The difference between the two groups was statistically significant (P <0.05). After one year follow-up, the recurrence rate was 40.00% in the experimental group and 100.00% in the control group, with significant difference between the two groups (P <0.05). Conclusion Azathioprine treatment of patients with refractory ulcerative colitis, can improve the treatment effect of the disease, it is worth promoting in practice.