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对消化系恶性肿瘤进行综合治疗,是提高患者5年生存率和生存质量的关键.手术前后的化疗,常因毒性反应过大、病人不能耐受而告终止.我科于1994年7月～1995年10月收治63例消化系统恶性肿瘤患者,在手术和化疗的同时给予保尔佳(Polyerga)治疗取得了较好的疗效.1 临床资料患者,男41例,女22例.年龄36～71岁,平均52岁.原发性肝癌6例(结节型),进展期胃癌19例,其中11例为腺癌,2例未分化癌,6例粘液癌.结肠癌11例,Duck’s分期B～C,其中腺癌4例,粘液癌5例,未分化癌2例.直肠癌15例,Duck’s分期均为C期,其中腺癌10例,粘液癌3例,未分化癌2例.胆管癌2例.以上病例均经病理检查确诊.63例均于术前1周结合化疗给药至术后8～12周.用法:
Comprehensive treatment of digestive malignancies is the key to improving patients’ 5-year survival rate and quality of life. Chemotherapy before and after surgery is often terminated due to excessive toxicity and patient intolerance. Our department was established in July 1994. In October 1995, 63 patients with malignant tumors of the digestive system were treated, and Polyerga treatment was given at the same time as surgery and chemotherapy. 1 Clinical data: 41 males and 22 females. 71 years old, average 52 years old. 6 cases of primary liver cancer (nodular type), 19 cases of advanced gastric cancer, including 11 cases of adenocarcinoma, 2 cases of undifferentiated carcinoma, 6 cases of mucinous carcinoma, 11 cases of colon cancer, Duck’s stage B ~ C, including 4 cases of adenocarcinoma, 5 cases of mucinous carcinoma, 2 cases of undifferentiated carcinoma, 15 cases of rectal cancer, Duck’s stage are C stage, including 10 cases of adenocarcinoma, 3 cases of mucinous carcinoma, 2 cases of undifferentiated carcinoma. There were 2 cases of cholangiocarcinoma. All the above cases were diagnosed by pathological examination. 63 cases were combined with chemotherapy for 1 week before surgery and 8-12 weeks after operation.