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对连续服用国产低剂量复方炔诺酮(1号片)和低剂量复方18-甲基炔诺酮(复方18甲)5～25年及同期使用宫内节育器(IUD)的健康妇女457例进行动脉压测定,对血压均值、高血压患病的危险性及其影响因素进行分析。结果表明:与同期IUD对照比较,长期服用低剂量复方避孕片(COC)有升高血压的作用,且1号片大于复方18甲(P<0.01)。分层分析表明连续使用低剂量口服避孕药(OC)15年以上增加患高血压的危险性,1号片组的相对危险度(RR)为3.36(95％CI1.62,6.97 P<0.01),复方18甲组的RR值为2.27(95％CI 1.05,4.88 P<0.05)。Logistic回归分析提示:从事农业生产劳动、有心脑疾患家族史、体质指数、使用COC及长期摄入COC的总剂量为高血压有显著意义的影响因素。研究结果还表明该人群中确诊高血压者已知血压高的比例较低,仅15％～30％。建议在服OC妇女中定期监测血压,在血压达正常高限的妇女中开展高血压一级预防,降低高血压患病危险性。
To 457 healthy women who took continuous domestic low-dose compound norethindrone (No.1 tablet) and low-dose compound 18-norethindrone (18 A) for 5 ~ 25 years and the same period with intrauterine device (IUD) Arterial pressure measurement, the average blood pressure, the risk of hypertension and its influencing factors were analyzed. The results showed that long-term use of low-dose compound contraceptive tablets (COC) had the effect of increasing blood pressure compared with the same period of IUD control, and the No.1 tablet was larger than the compound 18 A (P <0.01). Hierarchical analysis showed that the relative risk (RR) of group 1 was 3.36 (95% CI 1.62, 6.97, P <0.01) after continuous use of low dose oral contraceptives (OC) for more than 15 years increased the risk of developing hypertension. , And the RR of compound 18 group A was 2.27 (95% CI 1.05, 4.88 P <0.05). Logistic regression analysis indicated that the total dose of labor for agricultural production, family history of cardiovascular and cerebrovascular diseases, body mass index, the use of COC and long-term intake of COC has a significant impact on hypertension. The results also show that the proportion of people with known high blood pressure is low, only 15% to 30%. It is recommended to regularly monitor blood pressure in OC women and to develop a primary prevention of hypertension in women with normal blood pressure and reduce the risk of hypertension.