论文部分内容阅读
Bursting of excitatory neurons in pre-B(o)tzinger complex (pre-B(o)tC) of the mammalian brain stem is important to realize the respiratory rhythm.The different currents are intrinsic for bursting rhythms.Moreover,for many currents the dynamics of the bursting oscillation are very different.Persistent sodium (NaP) and calcium activated nonspecific cationic (CAN) currents play important roles in respiratory rhythm generation in neurons of the pre-B?tC.In order to study how these dynamics may arise from networks,we consider a two-coupled cell network of excitatory neuron within the pre-B?tzinger complex.In this paper,we study the bursting patterns and transition mechanisms in the two-parameter space of a two-cell network model of the pre-B?tC with synaptic coupling.By both fast/slow decomposition and two-parameter bifurcation analysis,we divide the two-parameter space of the NaP conductance and the CAN conductance into four different regions according to the multi-phases oscillations,and investigate the possible transition mechanisms of bursting between these regions.We also study the dynamics of the system with the synaptic coupling strength varying.This work will provide a further understanding of how NaP,CAN currents and synaptic couple work in respiratory rhythm generation.