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自从Crown报道了一些二烃基锡衍生物具有抗癌活性以来,这一领域的研究引起了人们极大的兴趣。许多二烃基锡衍生物被制备得到,并且测定了它们在离体及活体情况下的抗癌活性。本文综述了二烃基锡衍生物抗癌活性的研究进展,包括化合物的结构类型,抗癌作用机制以及利用QSAR方法对有机锡化合物的抗癌活性进行计算预测等。
Research in this area has drawn great interest since Crown reported that some of the dihydrocarbyltin derivatives have anticancer activity. Many dihydrocarbyl tin derivatives have been prepared and their anticancer activity determined ex vivo and in vivo. This review summarizes the research progress on the anticancer activity of dihydrocarbyltin derivatives, including the structure and type of compounds, the mechanism of anticancer action and the calculation and prediction of anticancer activity of organotin compounds by QSAR method.