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目的总结氟喹诺酮类药物在临床应用中的不良反应发生规律及特点,为临床合理用药提供依据。方法回顾性分析我院2008～2011年间收治的92例使用氟喹诺酮类药物后出现不良反应患者的临床资料。结果氟喹诺酮类药物不良反应发生率男性高于女性,60岁以上患者的药物不良反应发生例数最多,占58.7%,且随着年龄的增大药物不良反应发生的几率也随之增大。诺氟沙星和左氧氟沙星引起的不良反应共占81.6%,不良反应临床表现主要以消化道反应为主,静脉给药致不良反应发生率高于口服给药。结论临床使用氟喹诺酮类药物要严格掌握用药指征,严格掌握适应证,科学选择用药剂量和给药途径,保证用药安全,以降低不良反应的发生率。
Objective To summarize the regularities and characteristics of adverse reactions of fluoroquinolones in clinical application and provide the basis for clinical rational drug use. Methods The clinical data of 92 patients with adverse reactions after treatment with fluoroquinolone in our hospital from 2008 to 2011 were retrospectively analyzed. Results The incidence of adverse reactions of fluoroquinolones was higher in males than in females. The number of adverse drug reactions in patients over 60 years old was the highest (58.7%), and the incidence of adverse reactions increased with age. Adverse reactions caused by norfloxacin and levofloxacin accounted for 81.6%. The clinical manifestations of adverse reactions were mainly gastrointestinal reactions. The incidence of adverse reactions caused by intravenous administration was higher than that of oral administration. Conclusion Clinical use of fluoroquinolones should strictly control indications, strict indications, the scientific choice of dosage and route of administration, to ensure drug safety, in order to reduce the incidence of adverse reactions.