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选择同期入院的60例不稳定心绞痛患者,随机分为常规治疗组(对照组)和在常规治疗基础上加用肝素钙(治疗组)各30例进行疗效观察。结果表明:治疗组对不稳定心绞痛临床疗效达90.0％,与对照组疗效56.6％比较差异有高度显著性(P<0.01);心绞痛缓解或消失平均时间以及ST段下移及T波倒置回升作用均优于对照组(P<0.05或P<0.01)。治疗组治疗前后血液流变学参数比较提示:肝素钙可逆转不稳定心绞痛高粘高凝状态,抗冠脉内血栓形成,预防和减少急性心肌梗塞发生。认为小剂量肝素钙治疗不稳定心绞痛方法简便,安全可靠,疗效满意,也可作为急性心肌梗塞二级预防的一项积极有效新措施,有临床推广应用价值。
Sixty patients with unstable angina pectoris who were hospitalized in the same period were randomly divided into conventional treatment group (control group) and 30 patients on the basis of routine treatment with heparin calcium (treatment group). The results showed that the treatment group had a clinical efficacy of 90.0% for unstable angina, which was significantly higher than that of the control group (56.6%) (P <0.01); the mean time to ease or disappear of angina pectoris and the down-shift of ST segment and the inversion of T wave All were better than the control group (P <0.05 or P <0.01). The treatment group before and after treatment of hemorheology parameters suggest that: heparin calcium can reverse hyperviscosity of unstable angina pectoris, anti-coronary thrombosis, prevention and reduction of acute myocardial infarction. That small doses of heparin treatment of unstable angina pectoris method is simple, safe and reliable, with satisfactory results, but also as a secondary prevention of acute myocardial infarction is a positive and effective new measures, the clinical application value.