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目的分析天台县妇女宫颈人乳头状瘤病毒(HPV)感染情况及亚型分布。方法采用HPV-PCR反向斑点杂交技术对宫颈脱落细胞标本进行HPV分型检测。结果 3 253例样本中,检出HPV阳性者781例,阳性率为24.01%,检出22种亚型,其中高危型、低危型和高低危合并感染分别为539例(69.01%)、129例(16.52%)和113例(14.47%)。HPV单一亚型感染546例(69.91%),多重感染235例(30.09%)。不同年龄组HPV感染高峰在≤20岁、51岁~和>60岁,感染率分别为37.50%、31.39%和26.84%。主要感染亚型为HPV16、HPV52、HPV58、HPV81、HPV33、HPV18。结论女性HPV感染呈普遍化趋势,各年龄组检测阳性率差异有统计学意义(P<0.05),对≤20岁及>50岁的妇女应予以重视,对阳性患者要定期随访,对育龄妇女进行HPV基因分型检测有利于宫颈癌的早期预警和治疗。
Objective To analyze the prevalence and subtype distribution of cervical papilloma virus (HPV) in women in Tiantai County. Methods HPV-PCR reverse dot blot hybridization was used to detect HPV type in cervical exfoliated cells. Results Among 3 253 samples, 781 were positive for HPV, the positive rate was 24.01%. Totally 22 subtypes were detected, of which 539 (69.01%) were high risk, low risk and high risk. Cases (16.52%) and 113 cases (14.47%). 546 cases (69.91%) were infected with HPV subtypes, and 235 cases (30.09%) were infected with multiple infections. The incidence of HPV infection in different age groups was ≤20 years old, 51 years old and> 60 years old. The infection rates were 37.50%, 31.39% and 26.84% respectively. The main subtypes of infection are HPV16, HPV52, HPV58, HPV81, HPV33, HPV18. Conclusion The prevalence of HPV infection in women is generalized. The positive rate of HPV infection in all age groups is statistically significant (P <0.05). Women ≤20 and> 50 years old should be paid attention to, HPV genotyping test is conducive to early warning and treatment of cervical cancer.