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目的:探讨多囊卵巢综合征(PCOS)患者血清中核因子-κB(NF-κB)、转化生长因子β1(TGF-β1)的表达,及NF-κB、TGF-β1与胰岛素抵抗(IR)的相关性。方法:收集108例PCOS患者作为PCOS组,47例正常女性作为对照组,根据体质量指数(BMI)将其分为肥胖组(BMI≥28 kg/m2)与非肥胖组(BMI<28 kg/m2),根据胰岛素抵抗指数(HOMA-IR)将PCOS患者分为IR组(HOMA-IR≥2.69)及非IR组(HOMA-IR<2.69);应用酶联免疫法测量受试者血清中NF-κB、TGF-β1水平,同时对入组患者进行葡萄糖耐量(OGTT)及胰岛素释放(IRT)测定。结果:①PCOS患者血清中NF-κB、TGF-β1明显高于对照组(P<0.05),PCOS-IR组NF-κB、TGF-β1明显高于PCOS非IR组(P<0.05);②Pearson相关分析显示,NF-κB、TGF-β1与PCOS患者的雄激素(T)水平、BMI、HOMA-IR呈正相关(P<0.05)。结论:NF-κB、TGF-β1与PCOS患者T水平、IR密切相关,TGF-β1与NF-κB亦呈正相关,NF-κB、TGF-β1与PCOS密切相关。
Objective: To investigate the expression of nuclear factor-κB (NF-κB) and transforming growth factor-β1 (TGF-β1) in sera of patients with polycystic ovary syndrome (PCOS) and the correlation between the expressions of NF-κB, TGF-β1 and insulin resistance Correlation. Methods: A total of 108 patients with PCOS were selected as the PCOS group and 47 normal women as the control group. According to body mass index (BMI), they were divided into obesity group (BMI≥28 kg / m2) and non-obese group (BMI <28 kg / m2). PCOS patients were divided into IR group (HOMA-IR≥2.69) and non-IR group (HOMA-IR <2.69) according to HOMA-IR. Enzyme linked immunosorbent assay -κB, TGF-β1 levels were measured, and glucose tolerance (OGTT) and insulin release (IRT) were measured. Results: ① The serum levels of NF-κB and TGF-β1 in PCOS patients were significantly higher than those in control group (P <0.05), and the levels of NF-κB and TGF-β1 in PCOS-IR group were significantly higher than those in PCOS non-IR group Analysis showed that the levels of androgen (T), BMI and HOMA-IR in NF-κB and TGF-β1 were positively correlated with PCOS (P <0.05). CONCLUSIONS: The levels of NF-κB and TGF-β1 are closely related to T level and IR in PCOS patients. TGF-β1 and NF-κB are also positively correlated. NF-κB and TGF-β1 are closely related to PCOS.