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目的观察国产双氢青蒿素哌喹片治疗恶性疟疾的临床效果。方法在援尼日尔共和国工作期间采用随机分组的方法,将224例恶性疟疾患者分为治疗组和对照组,各112例,治疗组口服双氢青蒿素哌喹片(商品名为科泰复,每片含双氢青蒿素40mg、磷酸哌喹320mg),首剂2片,8、24和32h分别服2片,一个疗程共8片;对照组用双氢青蒿素片(商品名为科泰新,每片60mg),每天1片,首剂加倍,7d为1疗程,共8片。观察和记录病例的临床症状和药物的副作用。结果治疗组和对照组的临床治愈率为100%和96.4%,两组差异无统计学意义(P>0.05);平均退热时间为(36.16±13.32)和(40.42±15.63)h,两组差异有统计学意义(P<0.05),治疗组短于对照组;复燃率为3.6%和13.4%。两组差异有统计学意义(P<0.01),治疗组低于对照组。结论国产双氢青蒿素哌喹片治疗非洲恶性疟疾效果明显,临床治愈率高,退热时间缩短,复燃率降低,无明显毒副作用,可作为治疗普通型恶性疟疾的首选药物。
Objective To observe the clinical effect of domestic dihydroartemisinin and piperaquine tablet in the treatment of falciparum malaria. Methods A total of 224 cases of patients with malignant malaria were divided into treatment group and control group by randomization during the work in the Republic of Niger, 112 cases in each group. The treatment group received oral administration of dihydroartemisinin, Each containing dihydroartemisinin 40mg, piperacillin phosphate 320mg), the first dose of 2, 8,24 and 32h were served 2 tablets, a course of a total of 8; control group with dihydroartemisinin tablets (trade name Ketai new, each 60mg), 1 tablet daily, the first dose doubled, 7d for a course of treatment, a total of 8 tablets. Observe and record the clinical symptoms of the case and drug side effects. Results The clinical cure rates in the treatment group and the control group were 100% and 96.4%, respectively, with no significant difference between the two groups (P> 0.05). The mean duration of fever was (36.16 ± 13.32) and (40.42 ± 15.63) The difference was statistically significant (P <0.05), the treatment group was shorter than the control group; the rate of reactivation was 3.6% and 13.4%. The difference between the two groups was statistically significant (P <0.01), the treatment group was lower than the control group. Conclusions Domestic dihydroartemisinin and piperaquine tablets are effective in treating malignant malaria in Africa. The clinical cure rate is high, the antipyretic time is shortened and the rate of relapse is reduced. The drug has no obvious side effects and can be used as the drug of choice for treating common malaria.