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目的探讨男性原发不育与染色体异常的关系。方法对来自广东省计划生育专科医院不育门诊的2656例男性原发不育患者进行染色体核型分析。结果在这2656例男性患者中,共检出异常核型417例,染色体异常发生率为15.70%(417/2656)。其中性染色体数目异常339例,占总异常的81.29%(339/417),性染色体结构异常28例,占6.71%(28/417),常染色体数目异常2例,占0.48%(2/417),常染色体结构异常44例,占10.55%(44/417)。对染色体异常患者进行精液常规分析。结论染色体异常是造成男性原发不育的重要遗传因素,染色体检查对男性原发不育患者的诊断与治疗有重要意义。
Objective To explore the relationship between male primary infertility and chromosomal abnormalities. Methods Chromosomal karyotype analysis was performed on 2656 cases of primary male infertility from infertility clinics of family planning hospitals in Guangdong Province. Results Of the 2656 male patients, 417 abnormal karyotypes were detected, and the incidence of chromosomal abnormalities was 15.70% (417/2656). There were 339 cases with abnormal chromosome number, accounting for 81.29% (339/417) of the total abnormality, 28 cases with abnormal sex chromosome structure (6.71%, 28/417), 2 cases with an autosomal abnormality (0.48%, 2/417 ), Autosomal abnormalities in 44 cases, accounting for 10.55% (44/417). Chromosome abnormalities in patients with routine analysis of semen. Conclusion Chromosomal abnormalities are the important genetic factors that cause primary infertility in males. Chromosome examination is of great significance for the diagnosis and treatment of males with primary infertility.