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目的:通过丹参涂膜剂用于移植人体肥厚性瘢痕裸鼠模型,以观察对瘢痕内细胞因子TGF-β1和bFGF的影响,探讨丹参活血化瘀中药抗肥厚性瘢痕的作用机制,为临床中医预防和治疗瘢痕用药提供实验依据。方法:制作丹参涂膜剂,用于移植人体肥厚性瘢痕裸鼠模型,免疫组化EnVision法检测细胞因子TGF-β1、bFGF的表达。结果:丹参涂膜剂可促使瘢痕组织内细胞因子TGF-β1的表达明显下降,可增强瘢痕组织内细胞因子bFGF的表达。结论:丹参活血化瘀中药具有抑制瘢痕组织内细胞因子TGF-β1的表达和增强瘢痕组织内细胞因子bFGF的表达,从而具有抑制瘢痕的作用。
OBJECTIVE: To observe the effect of Salvia Miltiorrhiza on the hypertrophic scars in nude mice model by observing the effects of Salvia miltiorrhiza on hypertrophic scars in human hypertrophic scars. Prevention and treatment of scar medication to provide experimental evidence. Methods: Salvia miltiorrhiza film was prepared for the transplantation of hypertrophic scar in nude mice model. EnVision method was used to detect the expression of TGF-β1 and bFGF. Results: Salvia miltiorrhiza film-coated agent could promote the expression of cytokine TGF-β1 in scar tissue and increase the expression of bFGF in scar tissue. Conclusion: Danshen Huoxue Huayu Chinese medicine can inhibit the expression of cytokine TGF-β1 in scar tissue and enhance the expression of bFGF in scar tissue, which can inhibit the scarring.