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吡那地尔(Pinacidil)主要作用于毛细血管前阻力血管,通过扩张血管而降压。吡那地尔单用或与氢氯噻嗪合用,均能对高血压起到良好的治疗作用。对健康人的试验表明,食物不影响该药速释片剂的药动学。对高血压病人,本品的缓释剂型既可加大剂量间隔,又能延长降压作用,同时也避免了用药初期高血浓度所致的某些副作用。作者对8名健康受试者试验表明,食物对口服吡那地尔缓释片(一日2次)的吸收速率有影响,口服单剂缓释片25mg后,进餐后的血药浓度略高于禁食时的血药浓度。禁
Pinacidil acts mainly on the pre-capillary resistance vessels and depresses the blood vessels by dilating blood vessels. Pinacidol alone or combined with hydrochlorothiazide, can play a good therapeutic effect on hypertension. Tests on healthy people show that the food does not affect the pharmacokinetics of the immediate-release tablet. For hypertensive patients, the sustained-release dosage forms of the product can not only increase the dose interval, but also prolong the antihypertensive effect, and at the same time, avoid certain side effects caused by the high blood concentration in the initial period of medication. The study of eight healthy subjects showed that food had an effect on the rate of absorption of an extended-release pinacidil tablet (twice a day). After oral administration of a single-dose sustained-release tablet of 25 mg, the plasma concentration after meal was slightly higher Blood concentration during fasting. ban