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目的观查斯锑黑克治疗荒漠型黑热病的临床效果。方法 r K39金标法和ELISA夹心法检测黑热病抗体,B超仪测量脾脏的长度和厚度,全自动分析仪进行血液及生化检测。结果荒漠型黑热病患者42例,黑热病抗体全部阳性;治疗前脾脏的长度和厚度分别为正常的1.67倍和1.81倍,治疗后基本恢复正常;白细胞、红细胞、血红素、血小板治疗后显著升高(t值为3.633~6.422,P<0.01),草转氨酶降低(t值为2.455,P<0.05),恢复正常,前后差异具有统计学意义(P<0.05)。治疗前后血清球蛋白、谷丙转氨酶均处于正常范围。结论荒漠型黑热病的主要症状为脾脏肿大,严重贫血,营养不良,肝功能损伤;本次用斯锑黑克治疗荒漠型黑热病的总剂量为(278.4±39.2)mg/kg,分6次~10次给药,(16±6)d全部出院,至今6年没有发现复发或再感染。
Objective To observe the clinical effect of Chaoshenkaike in treating desert kala-azar disease. Methods K39 gold standard method and ELISA sandwich method for detection of kala-azar antibody, B-measure the length and thickness of the spleen, automatic analyzer for blood and biochemical tests. Results The results showed that 42 cases of desert kala-azar were all positive for kala-azar antibody. The length and thickness of the spleen before treatment were 1.67 and 1.81 times of normal, respectively, and returned to normal after treatment. The levels of white blood cells, erythrocytes, hemoglobin and platelets were significantly increased (t = 3.633 ~ 6.422, P <0.01), and the level of grass aminotransferase decreased (t = 2.455, P <0.05) and returned to normal. There was significant difference between before and after treatment (P <0.05). Serum globulin and alanine aminotransferase were in the normal range before and after treatment. Conclusion The main symptoms of desert-type kala-azar were splenomegaly, severe anemia, malnutrition and liver damage. The total dose of azathis-based antimicrobial therapy was 278.4 ± 39.2 mg / kg, 10 doses, (16 ± 6) d all discharged, so far no recurrence or re-infection 6 years.