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目的:观察和评价分析肝动脉灌注化疗栓塞术(TACE)联合复方苦参注射液治疗肝恶性肿瘤的疗效与安全性。方法:选取2013年12月—2015年12月收治的肝恶性肿瘤患者共60例,分析肝动脉灌注化疗栓塞术(TACE)联合复方苦参注射液治疗前后患者肝功能的变化规律。结果:与术前1周比较,术后1 d天冬氨酸氨基转氨酶(AST)、谷氨酸氨基转氨酶(ALT)、直接胆红素(DBIL)及总胆红素(TBIL)均明显升高(P<0.05),术后1周ALT,DBIL及TBIL均明显升高,差异均有统计学意义(P<0.05)。术前1周与术后4~6周患者的Child-Pugh分级A,B级及Child评分差异均有统计学意义(P<0.05)。肝恶性肿瘤患者的肝功能变化与治疗次数、是否合并肝硬化及门脉癌栓相关(P<0.05)。结论:肝动脉灌注化疗栓塞术(TACE)联合复方苦参注射液治疗肝恶性肿瘤患者,效果明显,于30 d左右即可恢复至术前水平,值得临床推广使用。
Objective: To observe and evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with Compound Kushen Injection in the treatment of hepatic malignancies. Methods: A total of 60 patients with malignant liver tumors were enrolled from December 2013 to December 2015. The changes of hepatic function in patients with hepatic arterial chemoembolization (TACE) and compound Kushen injection were analyzed before and after treatment. Results: AST, ALT, DBIL and total bilirubin (TBIL) were significantly increased 1 d after operation (P <0.05). The levels of ALT, DBIL and TBIL were significantly increased at 1 week after operation (P <0.05). There were significant differences in Child-Pugh grading A, B and Child scores between preoperative 1 week and postoperative 4 to 6 weeks (P <0.05). Liver function changes in patients with liver cancer were related to the number of treatment, cirrhosis and portal vein tumor thrombus (P <0.05). Conclusion: Hepatic arterial chemoembolization (TACE) combined with compound Kushen injection in patients with hepatic malignancies, the effect is obvious, about 30 d can be restored to the preoperative level, worthy of clinical promotion and use.