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为探讨肿瘤血管生成与喉鳞状细胞癌转移及预后的关系,我们采用免疫组化 SP 法用抗 FⅧ因子多克隆抗体对36例声门上型喉癌(T_1～T_2)内的血管进行标记及分析,结果显示:淋巴结转移组血管密度(30.52±5.31)明显高于无淋巴结转移组(16.28±6.15)(P<0.01)。随访发现,血管密度高表达组和低表达组,颈淋巴结术后复发率分别为66.67%和9.52%,两者比较有显著的统计学意义(P<0.01)。研究结果表明,肿瘤内血管密度与喉鳞癌转移密切相关,它可作为判定喉癌转移的预后指标。
To explore the relationship between tumor angiogenesis and metastasis and prognosis of laryngeal squamous cell carcinoma, we used immunohistochemical SP method to mark the blood vessels in 36 cases of T 1 ~ T 2 with anti-F factor polyclonal antibody The results showed that the vessel density in lymph node metastasis group (30.52 ± 5.31) was significantly higher than that in non - lymph node metastasis group (16.28 ± 6.15) (P <0.01). Follow-up revealed that the recurrence rates of cervical lymph nodes were 66.67% and 9.52% respectively in the group of high density and low expression of vascular density, both of which had significant statistical significance (P <0.01). The results showed that the density of tumor in the tumor is closely related to the metastasis of laryngeal squamous cell carcinoma, which can be used as a prognostic indicator of laryngeal cancer metastasis.