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目的比较血清CEA、CA19-9、CA12-5、CA72-4、CA50对胃癌临床诊断及疗效观察的价值。方法分别采用电化学发光和放射免疫方法检测30例胃癌患者(其中淋巴转移15例,未转移15例)血清中CEA、CA19-9、CA12-5、CA72-4和CA50水平,同时留取30例健康者血清作对照。结果胃癌患者CEA、CA19-9、CA12-5、CA72-4含量明显升高(P<0.01),联合检测CEA、CA19-9、CA50具有重要价值。胃癌患者治疗后CA19-9、CA50含量下降明显(P<0.05),5项标志物在淋巴转移患者血清中均高度表达,CA19-9、CA50尤其显著(P<0.01)。结论联合检测CEA、CA19-9、CA50对胃癌的诊断具有重要临床价值。
Objective To compare the clinical value of serum CEA, CA19-9, CA12-5, CA72-4 and CA50 in the diagnosis and therapeutic effect of gastric cancer. Methods The levels of CEA, CA19-9, CA12-5, CA72-4 and CA50 in serum of 30 patients with gastric cancer (15 cases of lymphatic metastasis and 15 cases of non-metastasis) were detected by electrochemiluminescence and radioimmunoassay. At the same time, 30 Cases of healthy serum as a control. Results The levels of CEA, CA19-9, CA12-5 and CA72-4 were significantly increased in patients with gastric cancer (P <0.01). The combined detection of CEA, CA19-9 and CA50 was of great value. The levels of CA19-9 and CA50 in gastric cancer patients decreased significantly (P <0.05), and all five markers were highly expressed in the serum of patients with lymph node metastasis, especially for CA19-9 and CA50 (P <0.01). Conclusion The combined detection of CEA, CA19-9, CA50 has important clinical value in the diagnosis of gastric cancer.