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缩宫素(催产素)的生物测定方法很多,美国药典20版和英国药典1980版采用鸡血压法,后者还采用大鼠子宫法及哺乳大鼠的乳汁挤压法。中国药典77版采用大鼠子宫法。还有报道用小鼠子宫法测定效价的。为此我们对鸡血压法、大鼠子宫法和小鼠子宫法进行了比较,为修改85版中国药典附录生测部分提供实验依据。
There are many bioassay methods for oxytocin (oxytocin). The 20th edition of the United States Pharmacopoeia and the British Pharmacopoeia 1980 adopt the chicken blood pressure method. The latter also uses the rat uterus method and the milk extrusion method of suckling rats. The Chinese Pharmacopoeia 77 uses the rat uterus method. It has also been reported that mouse uterine assays are used to determine titer. For this purpose, we compared the chicken blood pressure method, the rat uterus method and the mouse uterus method, and provided experimental evidence for modifying the biometric part of the 85th edition of the Chinese Pharmacopoeia.