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目的 探讨胃癌根治术中腹腔化疗对患者术后生存期的影响。方法 回顾性分析哈尔滨医科大学肿瘤医院 2 0 0 1年 63例胃癌根治术后患者 ,其中术中腹腔留置力尔凡与 5 -氟脲嘧啶者 2 7例 ,未留置者 3 6例 ,对比其 1年及 2年生存率。结果 Ⅱ期患者留置者 1年及 2年生存率分别为 10 0 %、83 .3 % ,未留置者分别为 87.5 %、75 % ;Ⅲ期患者留置者 1年及 2年生存率分别为80 %、70 % ,未留置者分别为 78.6%、5 7.1% ;Ⅳ期患者留置者 1年及 2年生存率分别为 81.8%、5 4.5 % ,未留置者分别为 78.6%、5 0 %。虽然各期留置药物者与未留置药物者 1年及 2年生存率经χ2 检验无显著性差异 ,但各期留置药物者的生存率均较未留置药物者有提高的趋势。结论 胃癌根治术中行腹腔化疗是值得继续临床观察和完善的改善手术效果和延长患者生存期的一种有益探索。
Objective To investigate the effect of intraperitoneal chemotherapy on the survival of patients after radical operation of gastric cancer. Methods Retrospective analysis of 63 patients with radical resection of gastric cancer in Cancer Hospital of Harbin Medical University from 2001 to 2001, including intraoperative laryngeal larvae and 5 - fluorouracil in 27 cases and 36 cases without lavage, compared with 1 year and 2 year survival rate. Results The 1-year and 2-year survival rates of stage Ⅱ patients were 100% and 83.3%, respectively, and 87.5% and 75% respectively. The 1-year and 2-year survival rates of stage Ⅲ patients were 80 %, 70%, 78.6%, 51.1% respectively. The 1-year and 2-year survival rates of stage IV patients were 81.8% and 54.5%, respectively. Although the 1-year and 2-year survival rates of patients with and without lupus drugs in each phase showed no significant difference by χ2 test, the survival rates of those with drugs in livers in all phases tended to increase compared with those without lupus drugs. Conclusions Intraperitoneal chemotherapy is a valuable exploration to continue the clinical observation and improve the surgical effect and extend the survival time of patients undergoing gastric cancer radical operation.